post-title portfolio-title Vincristine Sulfate 1 mg/ml solution for injection Taj Pharma 2020-01-24 05:23:15 no no
  1. Name of the medicinal product

Vincristine Sulfate 1 mg/ml solution for injection Taj Pharma

  1. Qualitative and quantitative composition

Each 1 ml contains 1 mg of vincristine sulfate

For the full list of excipients, see section 6.1.

  1. Pharmaceutical form

Solution for injection

A sterile, colourless solution.

  1. Clinical particulars

4.1 Therapeutic indications

Vincristine sulfate is used either alone or in conjunction with other oncolytic drugs for the treatment of:

  1. Leukaemias, including acute lymphocytic leukaemia, chronic lymphocytic leukaemia, acute myelogenous leukaemia and blastic crisis of chronic myelogenous leukaemia.
  2. Malignant lymphomas, including Hodgkin’s disease and non-Hodgkin’s lymphomas.
  3. Multiple myeloma.
  4. Solid tumours, including breast carcinoma, small cell bronchogenic carcinoma, head and neck carcinoma and soft tissue sarcomas.
  5. Paediatric solid tumours, including Ewing’s sarcoma, embryonal rhabdomyosarcoma, neuroblastoma, Wilms’ tumour, retinoblastoma and medulloblastoma.
  6. Idiopathic thrombocytopenic purpura. Patients with true ITP refractory to splenectomy and short-term treatment with adrenocortical steroids may respond to vincristine but the medicinal product is not recommended as primary treatment of this disorder. Recommended weekly doses of vincristine given for 3 to 4 weeks have produced permanent remissions in some patients. If patients fail to respond after 3 to 6 doses, it is unlikely that there will be any beneficial results with additional doses.

4.2 Posology and method of administration

Posology

The following dosage regimens have been used:

Adults:?The drug is administered intravenously at weekly intervals. The recommended dose is 1.4 to 1.5 mg/m2?up to a maximum weekly dose of 2 mg.

Children:?The suggested dose is 1.4 to 2 mg/m2?given on a weekly basis with a maximum weekly dose of 2 mg. For children weighing 10 kg or less the starting dose should be 0.05 mg/kg administered as a weekly intravenous injection.

Elderly:?The normal adult dose is still appropriate in the elderly.

Hepatic Impairment:?Because of the hepatic metabolism and biliary excretion of vincristine, reduced doses are recommended in patients with obstructive jaundice or other hepatic impairment. Patients with liver disease sufficient to decrease biliary excretion may experience an increase in the severity of side-effects. A 50 per cent reduction in the dose of vincristine sulfate is recommended for patients having a direct serum bilirubin value above 3 mg/100 ml (51 micromol/l).

Caution: If leakage into surrounding tissue should occur during intravenous administration of vincristine, it may cause considerable irritation. The injection should be discontinued immediately and any remaining portion of the dose should then be introduced into another vein. Local injection of the hyaluronidase and the application of moderate heat to the area of leakage help to disperse the drug and are thought to minimise discomfort and the possibility of cellulitis.

Method of administration

Precautions to be taken before handling or administering the medicinal product.

This preparation is for intravenous use only. It should only be administered by individuals experienced in vincristine administration.

FOR INTRAVENOUS USE ONLY

FATAL IF GIVEN BY ANY OTHER ROUTE

See section 4.4 for use for the treatment of patients given intrathecal vincristine sulfate.

Vincristine sulfate is administered by intravenous infusion at weekly intervals.

Great care should be exercised in calculating and administering the dose, as overdosage may be extremely serious or even fatal. The dose should not be increased beyond the level which produces therapeutic benefit. Individual doses should not exceed 2 mg; and white cell counts should be carried out before and after giving each dose.

With the vial presentations, do not add extra fluid to the vial prior to removal of the dose. Withdraw the solution of Vincristine Sulfate into an accurate dry syringe, measuring the dose carefully. Do not add extra fluid to the vial in an attempt to empty it completely.

It is recommended to infuse vincristine sulfate over 5 to 10 minutes after dilution in a 50 ml infusion bag with Sodium Chloride 9 mg/ml (0.9%) Solution for Injection. After administration the vein must be flushed through thoroughly. Care should be taken to avoid extravasation as this may cause local ulceration.

Because of the narrow range between therapeutic and toxic levels and variations in response, the dosage must always be adjusted to the individual.

For instructions on dilution of the medicinal product before administration, see section 6.6.

4.3 Contraindications

Intrathecal administration of vincristine sulfate is usually fatal.

Hypersensitivity to vincristine sulfate or to any of the excipients listed in section 6.1.

Patients with the demyelinating form of Charcot-Marie-Tooth syndrome should not be given vincristine.

Careful notice should also be given to those conditions listed in Section 4.4 Special warnings and precautions for use.

4.4 Special warnings and precautions for use

Warnings

This preparation is for intravenous use only. It should be administered by physicians experienced in the administration of vincristine sulfate. Vincristine sulfate should not be given by intrathecal, intramuscular or subcutaneous injection. The intrathecal administration of vincristine sulfate usually results in death.

Syringes containing this product should be labelled ‘VINCRISTINE FOR INTRAVENOUS USE ONLY. FATAL IF GIVEN BY OTHER ROUTES’.

After inadvertent intrathecal administration, immediate neurosurgical intervention is required in order to prevent ascending paralysis leading to death. In a very small number of patients, life-threatening paralysis and subsequent death was averted but resulted in devastating neurological sequelae, with limited recovery afterwards.

Based on the published management of these survival cases, if vincristine is mistakenly given by the intrathecal route, the following treatment should be initiated?immediately after the injection:

  1. Removal of as much CSF as is safely possible through the lumbar access.
  2. Insertion of an epidural catheter into the subarachnoid space via the intervertebral space above initial lumbar access and CSF irrigation with lactated Ringer’s solution. Fresh frozen plasma should be requested and, when available, 25 ml should be added to every 1 litre of lactated Ringer’s solution.
  3. Insertion of an intraventricular drain or catheter by a neurosurgeon and continuation of CSF irrigation with fluid removal through the lumbar access connected to a closed drainage system. Lactated Ringer’s solution should be given by continuous infusion at 150 ml/h, or at a rate of 75 ml/h when fresh frozen plasma has been added as above.

The rate of infusion should be adjusted to maintain a spinal fluid protein level of 150 mg/dl.

The following measures have also been used in addition but may not be essential:

Folinic acid has been administered intravenously as a 100 mg bolus and then infused at a rate of 25 mg/h for 24 hours, then bolus doses of 25 mg 6-hourly for 1 week. Intravenous administration of glutamic acid 10 g over 24 hours, followed by 500 mg three times daily by mouth for one month. Pyridoxine has been given at a dose of 50 mg 8 hourly by intravenous infusion over 30 minutes. Their roles in the reduction of neurotoxicity are unclear.

Vincristine sulfate is a vesicant and may cause severe local reaction or extravasation, see?Caution?in section 4.2.

The vial stopper contains dry natural rubber (a derivative of latex), which may cause allergic reactions.

Precautions

Leucopenia is less likely following therapy with vincristine sulfate than is the case with other oncolytic agents. It is usually neuromuscular rather than bone marrow toxicity that limits dosage. However, because of the possibility of leucopenia, both physician and patient should remain alert for signs of any complicating infection. If leucopenia or a complicating infection is present, then administration of the next dose of vincristine sulfate warrants careful consideration. On occasions, these infections may prove fatal.

Acute uric acid nephropathy, which may occur after administration of oncolytic agents, has also been reported with vincristine sulfate.

As vincristine sulfate penetrates the blood-brain barrier poorly, additional agents and routes of administration may be required for central nervous system leukaemias.

The neurotoxic effect of vincristine sulfate may be additive with other neurotoxic agents or increased by spinal cord irradiation and neurological disease. Elderly patients may be more susceptible to the neurotoxic effects of vincristine sulfate.

Both in vivo and in vitro laboratory tests have failed to demonstrate conclusively that this product is mutagenic. Fertility following treatment with vincristine alone for malignant disease has not been studied in humans. Clinical reports of both male and female patients who received multiple-agent chemotherapy that included vincristine indicate that azoospermia and amenorrhoea can occur in post pubertal patients. Recovery occurred many months after completion of chemotherapy in some but not all patients. When the same treatment is administered to prepubertal patients, it is much less likely to cause permanent azoospermia and amenorrhoea.

Patients who received vincristine chemotherapy in combination with anticancer drugs known to be carcinogenic have developed second malignancies. The contributing role of vincristine in this development has not been determined. No evidence of carcinogenicity was found following intraperitoneal administration in rats and mice, although this study was limited.

Care should be exercised to avoid accidental contamination of the eyes as vincristine sulfate is highly irritant and can cause corneal ulceration. The eye should be washed immediately and thoroughly.

Vincristine can cause foetal harm when administered to a pregnant woman. Women of childbearing potential should be advised to avoid becoming pregnant while receiving vincristine (see sections 4.6 and 5.3).

4.5 Interaction with other medicinal products and other forms of interaction

The neurotoxicity of vincristine sulfate may be additive with that of isoniazid and other drugs acting on the nervous system.

Acute shortness of breath and severe bronchospasm have been reported following the administration of vinca alkaloids. These reactions have been encountered most frequently when the vinca alkaloid was used in combination with mitomycin-C and may be serious when there is pre-existing pulmonary dysfunction. The onset may be within minutes or several hours after the vinca is injected and may occur up to 2 weeks following the dose of mitomycin. Progressive dyspnoea, requiring chronic therapy, may occur. Vincristine should not be re-administered.

The simultaneous oral or intravenous administration of phenytoin and antineoplastic chemotherapy combinations, that included vincristine sulfate, have been reported to reduce blood levels of the anticonvulsant and to increase seizure activity. Although the contribution of the vinca alkaloids has not been established, dosage adjustment of phenytoin, based on serial blood level monitoring, may need to be made when it is used in combination with vincristine.

Caution should be exercised in patients concurrently taking drugs known to inhibit drug metabolism by hepatic cytochrome P450 isoenzymes in the CYP 3A subfamily, or in patients with hepatic dysfunction. Concurrent administration of vincristine sulfate with itraconazole (a known inhibitor of the metabolic pathway) has been reported to cause an earlier onset and/or an increased severity of neuromuscular side-effects (see Section 4.8 Undesirable effects). This interaction is presumed to be related to inhibition of the metabolism of vincristine.

When vincristine sulfate is used in combination with L-asparaginase, it should be given 12 to 24 hours before administration of the enzyme in order to minimise toxicity, since administering L-asparaginase first may reduce hepatic clearance of vincristine.

When chemotherapy is being given in conjunction with radiation therapy through portals which include the liver, the use of vincristine should be delayed until radiation therapy has been completed.

Vincristine sulfate appears to increase the cellular uptake of methotrexate by malignant cells and this principle has been applied in high-dose methotrexate therapy.

Severe hepatotoxicity, including veno-occlusive disease has been reported in patients treated with a combination of vincristine and dactinomycin for renal carcinoma.

4.6 Fertility, pregnancy and lactation

Pregnancy

Caution is necessary with the use of all oncolytic drugs during pregnancy. Both men and women receiving vincristine should be informed of the potential risk of adverse effects. Reliable methods of contraception or abstinence are recommended.

Vincristine can cause foetal harm following maternal or paternal exposure, although there are no adequate and well-controlled studies (see section 5.3). Women of childbearing potential should be advised to avoid becoming pregnant while receiving vincristine and use effective contraception during treatment.

If vincristine is used during pregnancy or if the patient becomes pregnant while receiving this medicinal product she should be informed of the potential hazard to the foetus.

There are no or limited amount of data from the use of vincristine sulfate in pregnant women. Studies in animals have shown reproductive toxicity (see section 5.3.)

Breast-feeding

There is insufficient information on the excretion of vincristine sulfate in human milk. A risk to the suckling child cannot be excluded. A decision must be made whether to discontinue breast-feeding or to discontinue/abstain from vincristine sulfate therapy, taking into account the benefit of breast-feeding for the child and the benefit of therapy for the woman.

4.7 Effects on ability to drive and use machines

No studies on the effects on the ability to drive and use machines have been performed.

4.8 Undesirable effects

In general, adverse reactions are reversible and are related to dosage size and cumulative dosage. The use of small amounts of vincristine daily for long periods is not advised. The most common adverse reaction is alopecia; the most troublesome adverse reactions are neuromuscular in origin.

When single weekly doses of vincristine are employed, the adverse reactions of leukopenia, neuritic pain, and constipation are usually of short duration (i.e. less than 7 days). When the dosage is reduced, these reactions may lessen or disappear. They seem to be increased when the calculated amount of medicinal product is given in divided doses. Other adverse reactions, such as alopecia, sensory loss, paraesthesia, difficulty in walking, slapping gait, loss of deep-tendon reflexes and muscle wasting may persist for at least as long as therapy is continued. Generalised sensorimotor dysfunction may become progressively more severe with continued treatment, but the neuromuscular difficulties may persist for prolonged periods in some patients. Re-growth of hair may occur while maintenance therapy continues.

The following adverse reactions have been reported:

Infections and infestations:?Infection, sepsis, neutropenic sepsis

Neoplasms benign, malignant and unspecified (incl cysts and polyps):?The occurrence of secondary malignancies has been reported rarely in patients treated with vincristine in association with other anticancer drugs known to be carcinogenic.

Blood and lymphatic system disorders: Leukopenia and neutropenia; vincristine does not appear to have any constant or significant effect upon the platelets or the red blood cells, however, anaemia, haemolytic anaemia and thrombocytopenia have been reported. If thrombocytopenia is present when treatment with vincristine sulfate is begun, it may actually improve before the appearance of marrow remission. Clinical consequences of leukopenia may be fever, infections and sepsis. There have been occasional reports of fatal infections during vincristine therapy.

Immune system disorders:?Rare cases of allergic-type reactions, such as anaphylaxis, rash and oedema, temporally related to vincristine therapy have been reported in patients receiving vincristine as a part of multi-drug chemotherapy regimens.

Endocrine disorders:?Rare occurrences of a syndrome attributable to inappropriate anti-diuretic hormone secretion have been observed in patients treated with vincristine. There is a high urinary sodium excretion in the presence of hyponatraemia; renal or adrenal disease, hypotension, dehydration, azotaemia and clinical oedema are absent. With fluid deprivation, improvement occurs in the hyponatraemia and in the renal loss of sodium.

Metabolism and nutrition disorders:?Anorexia.

Nervous system disorders (often dose limiting): Neuritic pain, sensory loss, paraesthesia, difficulty in walking, loss of deep tendon reflexes, ataxia, paresis, foot drop and cranial nerve palsies, especially ocular palsies and laryngeal nerve paralysis. Frequently, there appears to be a sequence in the development of neuromuscular side effects. Initially, one may encounter only sensory impairment and paraesthesia. With continued treatment, neuritic pain may appear and later, motor difficulties. No reports have yet been made of any agent that can reverse the neuromuscular manifestations of vincristine sulfate. Convulsions, frequently with hypertension, have been reported in a few patients receiving vincristine. Several instances of convulsions followed by coma have been reported in children.

Eye disorders:?Transient cortical blindness and optic atrophy with blindness have been reported.

Ear and labyrinth disorders:?Treatment with vinca alkaloids has resulted rarely in both vestibular and auditory damage to the eighth cranial nerve. Manifestations include partial or total deafness, which may be temporary or permanent, and difficulties with balance, including dizziness, nystagmus and vertigo. Particular caution is warranted when vincristine sulfate is used in combination with other agents known to be ototoxic, such as the platinum-containing oncolytics.

Cardiac disorders:?Chemotherapy combinations which have included vincristine, when given to patients previously treated with mediastinal radiation, have been associated with coronary artery disease and myocardial infarction. Causality has not been established.

Vascular disorders:?Hypertension and hypotension have occurred.

Respiratory, thoracic and mediastinal disorders:?Acute shortness of breath and severe bronchospasm have been reported following the administration of vinca alkaloids (see section 4.5).?Pharyngeal pain has also been reported.

Gastro-intestinal disorders: Constipation, abdominal cramps, paralytic ileus, diarrhoea, nausea, vomiting, oral ulceration, intestinal necrosis and/or perforation have occurred. The constipation which may be encountered responds well to such usual measures as enemas and laxatives. Constipation may take the form of upper colon impaction and the rectum may be found to be empty on physical examination. Colicky abdominal pain, coupled with an empty rectum, may mislead the clinician. A flat film of the abdomen is useful in demonstrating this condition. A routine prophylactic regimen against constipation is recommended for all patients receiving vincristine sulfate. Paralytic ileus may occur, particularly in young children. The ileus will reverse itself upon temporary discontinuance of vincristine and with symptomatic care. Parotid gland pain has also been reported.

Skin and subcutaneous tissue disorders: Alopecia, rash.

Musculoskeletal and connective tissue disorders:?Muscle wasting, jaw pain, bone pain, back paid, limb pain and myalgias have been reported; pain in these areas may be severe.

Renal and urinary disorders: Polyuria, dysuria and urinary retention due to bladder atony have occurred. Other drugs known to cause urinary retention (particularly in the elderly) should, if possible, be discontinued for the first few days following administration of vincristine.

General disorders and administration site conditions:?Fever, headache, injection site reaction (see Section 4.2 Posology and method of administration), slapping gait.

Investigations:?Weight loss.

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important.

4.9 Overdose

Side effects following the use of vincristine are dose related. In children under 13 years of age, death has occurred following doses of vincristine that were 10 times those recommended for therapy. Severe symptoms may occur in this patient group following dosages of 3 to 4 mg/m2. Adults can be expected to experience severe symptoms after single doses of 3 mg/m2?or more. Therefore, following administration of doses higher than those recommended patients can be expected to experience side-effects in an exaggerated fashion. Supportive care should include the following: (a) prevention of side-effects resulting from the syndrome of inappropriate antidiuretic hormone secretion (this would include restriction of fluid intake and perhaps the administration of a diuretic affecting the function of the loop of Henle and the distal tubule); (b) administration of anticonvulsants; (c) use of enemas or cathartics to prevent ileus (in some instances, decompression of the gastrointestinal tract may be necessary); (d) monitoring the cardiovascular system; (e) determining daily blood counts for guidance in transfusion requirements.

Folinic acid has been observed to have a protective effect in normal mice which were administered lethal doses of vincristine. Isolated case reports suggest that folinic acid may be helpful in treating humans who have received an overdose. A suggested schedule is to administer 100 mg of folinic acid intravenously every 3 hours for 24 hours and then every 6 hours for at least 48 hours. Theoretical tissue levels of vincristine derived from pharmacokinetic data are predicted to remain significantly elevated for at least 72 hours. Treatment with folinic acid does not eliminate the need for the above-mentioned supportive measures.

Most of an intravenous dose of vincristine is excreted into the bile after rapid tissue binding. Because only very small amounts of the drug appear in dialysate, haemodialysis is not likely to be helpful in cases of overdosage.

Enhanced faecal excretion of parenterally administered vincristine has been demonstrated in dogs pre-treated with cholestyramine. There are no published clinical data on the use of cholestyramine as an antidote in humans.

There are no published clinical data on the consequences of oral ingestion of vincristine. Should oral ingestion occur, the stomach should be evacuated followed by oral administration of activated charcoal and a cathartic.

  1. Pharmacological properties

5.1 Pharmacodynamic properties

Pharmacotherapeutic group: Antineoplastic agent – vinca alkaloid.

Mechanism of action

Vincristine is an antineoplastic drug with broad-spectrum anti-tumor activity in man. The drug may act by mitotic inhibition, causing an arrest of cell division in metaphase. The drug is relatively marrow-sparing and is thus suitable for use in combination with other cancer chemotherapeutic agents.

5.2 Pharmacokinetic properties

Vincristine is poorly absorbed orally. The clearance of the drug after rapid intravenous injection follows a triphasic decay pattern: a very rapid steep descent (alpha phase); a narrow-middle region (beta-phase) and a much longer terminal region (gamma phase). The terminal phase half-life of the drug varies from 15-155 hours.

Dosing with the drug more frequently than once weekly is therefore probably unnecessary.

Vincristine is primarily excreted by the biliary route.

Patients with impaired hepatic or biliary function, as evidenced by a raised serum alkaline phosphatase, have been shown to have a significantly prolonged vincristine elimination half-life.

5.3 Preclinical safety data

Both in vivo and in vitro laboratory tests have failed to demonstrate conclusively that this product is mutagenic. No evidence of carcinogenicity was found following intraperitoneal administration in rats and mice, although this study was limited.

In several animal species, vincristine can include teratogenic effects, as well as embryo lethality, with doses that are non-toxic to the pregnant animal.

  1. Pharmaceutical particulars

6.1 List of excipients

Mannitol

Water for injections

6.2 Incompatibilities

It is not recommended that vincristine sulfate should be mixed with any other drug and should not be diluted in solutions that raise or lower the pH outside the range 3.5 to 5.5. Furosemide both in syringe and injected sequentially into Y-site with no flush between, results in immediate precipitation.

6.3 Shelf life

2 years.

6.4 Special precautions for storage

Store in a refrigerator (2?C ? 8 ?C). Keep the vial in the outer carton, in order to protect from light.

6.5 Nature and contents of container

2 ml Type I clear glass vials, with rubber closures and aluminium caps in packs of 5 vials.

2 ml Type I clear Onco-Tain??vials, with rubber closures and aluminium caps in packs of 5 vials.

2.25 ml Type I clear glass, graduated, barrel syringes with luer lock as a single syringe pack.

Not all pack sizes may be marketed.

6.6 Special precautions for disposal and other handling

Cytotoxic Handling Guidelines

Administration:

Should be administered only by or under the direct supervision of a qualified physician who is experienced in the use of cancer chemotherapeutic agents.

Preparation (Guidelines)

  1. Chemotherapeutic agents should be prepared for administration only by professionals who have been trained in the safe use of preparation.
  2. Operations such as reconstitution of powder and transfer to syringes should be carried out only in the designated area.
  3. The personnel carrying out these procedures should be adequately protected with clothing, gloves and eye shield.
  4. Pregnant personnel are advised not to handle chemotherapeutic agents.

Contamination

(a) In the event of contact with the skin or eyes, the affected area should be washed with copious amounts of water or normal saline. A bland cream may be used to treat the transient stinging of skin. Medical advice should be sought if the eyes are affected.

(b) In the event of spillage, operators should put on gloves and mop the spilled material with a sponge kept in the area for that purpose. Rinse the area twice with water. Put all solutions and sponges into a plastic bag and then seal it.

Disposal

Syringes, containers, absorbent materials, solution and any other contaminated material should be placed in a thick plastic bag or other impervious container and incinerated.

7.Manufactured in India By:
TAJ PHARMACEUTICALS LIMITED
at SURVEY NO.188/1 TO 189/1,190/1 TO 4,
ATHIYAWAD, DABHEL, DAMAN- 396210 (INDIA).

Vincristine Sulfate 1 mg/ml solution for injection

Package leaflet: Information for the patient

Vincristine Sulphate 1 mg/ml Injection

Read all of this leaflet carefully before you start taking this medicine because it contains important information for you.
– Keep this leaflet. You may need to read it again.
?- If you have any further questions, ask your doctor or pharmacist.
– This medicine has been prescribed for you only. Do not pass it on to others. It may harm them, even if their signs of illness are the same as yours.
– If you get any side effects, talk to your doctor or pharmacist. This includes any possible side effects not listed in this leaflet (see section 4).

What is in this leaflet

1. What Vincristine Sulfate Injection is and what it is used for
2. What you need to know before you take Vincristine Sulfate Injection
3. How to take Vincristine Sulfate Injection
4. Possible side effects
5. How to store Vincristine Sulfate Injection
6. Contents of the pack and other information

1.WHAT VINCRISTINE SULFATE INJECTION IS AND WHAT IT IS USED FOR

Vincristine sulphate is an anti-cancer medicine. Treatment with an anti-cancer medicine is sometimes called cancer chemotherapy.
Vincristine Sulphate Injection is used in the treatment of cancers of the blood (eg. leukaemia or lymphomas), breast, head and neck or lung. It may be used to treat multiple myeloma (a cancer of plasma cells) and it may also be used in the treatment of some cancers in children. It may be used in a blood disorder known as idiopathic thrombocytopenic purpura (ITP) after other treatments have not been successful.

Vincristine Sulphate Injection may be given alone or in combination with other anticancer medicines.

  1. WHAT YOU NEED TO KNOW BEFORE YOU TAKE VINCRISTINE SULFATE INJECTION

Vincristine Sulphate Injection must never be injected intrathecally (into the spine).

Do not use Vincristine Sulphate Injection
?? if you have shown signs of hypersensitivity (severe allergy) to vincristine, benzyl alcohol or mannitol in the past
?? if you have Charcot-Marie-Tooth syndrome (disease which causes weaknessin the leg muscles)
?? if you have an infection that is not being treated

Tell your doctor if any of the above applies to you before this medicine is used

Premature babies or babies less than 4 weeks old must not receive Vincristine Sulphate Injection 5 mg/5 ml (see ?Important information about one of the ingredients of Vincristine Sulphate Injection? below).

Take special care with Vincristine Sulphate Injection
?? to make sure that this medicine is only given to you through a vein (it should? not be given by any other route). If you notice any pain during, or soon after the injection is given, tell your doctor or nurse immediately
?? if you have a mental or nervous system disorder
?? if you have liver trouble
?? if you have kidney cancer
?? if you are having radiotherapy
?? if you have breathing problems
?? if you have a low white blood cell count, measured on blood test
?? if you have an infection

Tell your doctor if any of the above applies to you before this medicine is used.

Special care is also needed if this medicine is given to the elderly or children between 4 weeks and 3 years old.

Other medicines and Vincristine Sulphate Injection
Tell your doctor if you are taking, have recently taken or might take any other medicines.

Use of the following medicines may make the side effects of vincristine sulphate worse:
?? isoniazid (medicine used to treat tuberculosis)
?? mitomycin-C (anti-cancer medicine)
?? itraconazole (a medicine used to treat fungal infections)
?? L-asparaginase (used for treating some types of cancer)
?? dactinomycin (used for treating some types of cancer)
?? some anti-cancer drugs (eg containing platinum) that may cause problems with hearing or balance
?? medicines which cause problems with passing water (urine). These should be stopped before you start treatment with vincristine
?? medicines which cause problems with your nervous system e.g. walking difficulties, pins and needle or numbness

Phenytoin (medicine used to control fits) may not work as well when vincristine sulphate is used, so blood levels of phenytoin will need to be monitored.

Methotrexate used in the treatment of cancer may work better when used with vincristine.

Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.

Pregnancy, breast-feeding and fertility
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.

Women of childbearing potential should use appropriate contraception methods during treatment with vincristine sulphate.

Driving and using machines
Do not drive or use machines if you experience any side effect which may lessen your ability to do so.

Important information about one of the ingredients of Vincristine Sulphate Injection
This medicine contains benzyl alcohol. This means that this medicine must not be given to premature babies or neonates. It may cause toxic reactions and allergic reactions in infants and children up to 3 years old.

Vincristine Sulphate Injection contains Latex
The vial stopper contains dry natural rubber (a derivative of latex), which may cause allergic reactions.

  1. HOW TO TAKE VINCRISTINE SULFATE INJECTION

This medicine is given by infusion (drip) into a vein.
Vincristine sulphate is an irritant, if it accidentally gets into your eye tell your doctor or nurse immediately so that it may be washed out.
You may be given medicines to prevent constipation during treatment with vincristine sulphate.

Dosage
Your doctor will work out the correct dose of vincristine sulphate for you and how often it must be given.
The dose will depend on your medical condition, your size and how well your liver is working. Your doctor will tell how well your liver is working using a blood sample.
Vincristine sulphate is usually given once a week.

If you are given too much or too little Vincristine Sulphate Injection
This medicine will be given to you in a hospital, under the supervision of a doctor. It is unlikely that you will be given too little or too much, however, tell your doctor or nurse if you have any concerns.

4.POSSIBLE SIDE EFFECTS

Like all medicines, vincristine sulphate can have side effects, although not everybody gets them.

If any of the following happen, tell your doctor immediately:
? severe allergic reaction ? you may experience a sudden itchy rash (hives),
? swelling of the hands, feet, ankles, face, lips, mouth or throat (which may cause difficulty in swallowing or breathing), and you may feel you are going to faint.? pain or swelling at the injection site during or immediately after the injection
?? severe chest pains possibly radiating to the jaw or arm, sweating,
? breathlessness and nausea? severe breathing problems or shortness of breath
?? Symptoms suggestive of sepsis ? these may include a high fever or low? temperature, shivering, fast heartbeat, rapid breathing, feeling faint, skin changes (cold, clammy and mottled or pale), altered mental state such as confusion or disorientation, decreased urination, nausea, vomiting etc. The presence of a few or several of these symptoms coupled with a rapid deterioration of general condition might indicate sepsis and immediate medical attention should be sought.

These are serious side effects. You may need urgent medical attention. All of these serious side effects are rare.

If any of the following happen, tell your doctor as soon as possible:
?? convulsions (fits)
?? deafness or hearing loss
? worsening eyesight
?? pain (may involve the side of the face, jaw, throat, neck, bones or muscles)
?? dizziness
?? fever, sore throat, skin rashes, or sores on your body and mouth ulcers (may? indicate a drop in white blood cells)
?? significant weight loss
?? numbness or pins and needles
?? difficulty in walking
?? muscle weakness or muscle wasting
?? difficulty with speech
?? unusual eye movements
?? problems with passing water (more or less urine than normal, or pain when passing urine)
?? mild breathing problems
?? raised or lowered blood pressure
?? headache
?? tiredness
?? unexpected bruises
?? stomach cramps, constipation or diarrhea
?? being sick or feeling sick
?? hair loss
?? soreness around the injection site after the injection
?? infections with germs
?? loss of appetite

Vincristine sulphate may lead to changes in your blood cells, including a type of anaemia in which red blood cells are destroyed (haemolytic anaemia). Your doctor may take blood samples to monitor for these and also to check how well your liver is working.

There have been reports of other malignancies (cancers) occurring at a later date after vincristine has been used in combination with other anti-cancer drugs. This happens rarely.

Effects on fertility
Treatment with vincristine sulphate may permanently reduce fertility in men and women. Tell your doctor if you have concerns.

By reporting side effects you can help provide more information on the safety of this medicine.

  1. HOW TO STORE VINCRISTINE SULFATE INJECTION

Keep this medicine out of the sight and reach of children

Expiry
This medicine must not be used after the expiry date which is stated on the vial label and carton after ‘EXP’. Where only a month and year is stated, the expiry date refers to the last day of that month.

Storage Conditions
Store in a refrigerator (2?C – 8 ?C). The vials should be kept in the outer carton, in order to protect from light.
Medicines should not be disposed of via waste water or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.

  1. CONTENTS OF THE PACK AND FURTHER INFORMATION

What Vincristine Sulfate Injection contain

The active substance is vincristine sulphate. Each millilitre (ml) of solution contains 1 milligram (mg) of vincristine sulphate.
The other ingredients are mannitol, benzyl alcohol and Water for Injections.

?What Vincristine Sulfate Injection look like and contents of the pack
Vincristine Sulphate Injection is a colourless solution which comes in glass containers called vials.
It may be supplied in packs containing 5 x 5 mg/5 ml vials.

7.Manufactured in India By:
TAJ PHARMACEUTICALS LIMITED
at SURVEY NO.188/1 TO 189/1,190/1 TO 4,
ATHIYAWAD, DABHEL, DAMAN- 396210 (INDIA).

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